Commercial silk sutures: Encapsulation1
Not your ordinary silk
Silk-derived biological SERI® Surgical Scaffold exhibits favorable biocompatibility with minimal inflammation1
All silks are not created equally. Ultra pure SERI® Surgical Scaffold is different from ordinary surgical silk.1,4,5
Ordinary silk sutures contain sericin, which is associated with an exaggerated inflammatory response.1,5
Only SERI® Surgical Scaffold undergoes a proprietary purified bioengineering process designed to remove sericin and other impurities for an ultra pure, sterile product.2
Ordinary silk sutures contain sericin, which is associated with an exaggerated inflammatory response.1,5
Raw silk fiber with its natural sericin coating and impurities3,4
- The components in silk sutures can cause excessive inflammation5
Commercial silk suture is made of fibrous proteins that are first processed into strands, then braided, and may be dyed and coated with wax or silicone.5 These silk sutures typically can become encapsulated and do not integrate into the native tissue.1
Only SERI® Surgical Scaffold undergoes a proprietary purified bioengineering process designed to remove sericin and other impurities for an ultra pure, sterile product.2
SERI® Surgical Scaffold + Tissue: Favorably integrates within the tissue1
Ultra pure, silk-derived fibroin after removal of the sericin encasement and other impurities4
- Ultra pure SERI® Surgical Scaffold demonstrates favorable integration and predictable bioresorption1
Tissue response to SERI® Surgical Scaffold exhibits minimal inflammation that is confined to the silk-derived scaffold. This helps promote favorable integration and neovascularization as the scaffold is bioreplaced over time with collagen.1
Methodology: In a rat abdominal wall model study of cell and tissue response to intramuscular implantation of SERI® Surgical Scaffold fibers and Sofsilk® nonresorbable silk sutures 28 days after implantation using histology.1
Note: Similar studies in humans have not been performed.